The mouse/keyboard is free after turn off monitor, Any help?

[Darksky]

I would suggest the same I suggested here:

Raspberry PI 5 : Possible kernel issue with SD Card?

I would first switch to the unstable branch and install the latest: linux-rpi5 (Version 6.6.18-1) (linux-rpi4 for the rpi4). rpi-overlays raspberrypi-bootloader raspberrypi-bootloader-x If the issue still exists with the latest packages then create an issue with the RPi kernel gitlab. I have not seen a similar issue reported here or on their gitlab.