I’m running 5.17 kernel just fine, but that being said I ALWAYS keep the last 2 working LTS kernels on my system as well so that if the latest kernel won’t boot I can simply reboot and select a different kernel from the grub menu. I’d recommend at a bare minimum to always keep at least 1 other LTS kernel that works with your system so that if for whatever reason the latest stable kernel breaks anything you have a quick and easy way to get working until the issue is resolved.