There is only one place where you save the settings to be applied system wide
In the left pane of the Nvidia settings window
In the corresponding right pane you have
In the botton of the left pane there is nvidia-settings Configuration and the corresponding right pane is also a save settings - but this one is creating a rc file which you can load per user base using the -l, --load-config-only option
$ nvidia-settings --help
Load the configuration file, send the values specified therein to the X s
erver, and exit. This mode of operation is useful to place in your xinit
rc file, for example.