When I try to launch ‘Add/remove programs’ application, the Plasma desk informs: ‘And and remove programs failed. Remote peer disconnected’.
Is this application still in use ?
Yes, very much - Restart the app usually work.
Else, see if there are any errors when launching it from the terminal. This is my working one just now:
$ pamac-manager
(pamac-manager:42514): Gtk-WARNING **: 11:52:49.174: Unknown key gtk-modules in /home/mirdarthos/.config/gtk-4.0/settings.ini
(pamac-manager:42514): Adwaita-WARNING **: 11:52:49.256: Using GtkSettings:gtk-application-prefer-dark-theme with libadwaita is unsupported. Please use AdwStyleManager:color-scheme instead.
No problems here on our latest installations at home.
My wife would kill me if this wouldn’t work any longer on her device
Please provide system information;
System Information
Output of this command (formatted according to forum requirements) may be useful for those wishing to help:
inxi --filter --verbosity=8
or the short form:
inxi -zv8
Be prepared to provide more information and outputs from other commands whenever asked.
You can try changing the Pamac version used;
If you currently use pamac-gtk3 (GTK3) this will replace it with pamac-gtk (GTK4);
sudo pacman -S pamac-gtk
Or, if using pamac-gtk (GTK4) already, try replacing it with pamac-gtk3 (GTK3);
sudo pacman -S pamac-gtk3
Either way, answer 'Y` when pacman asks to replace it.
Regards.
Mod edit: corrected typo in final command
@soundofthunder Thank you very much for your advice ! After running command sudo pacman -S pamac-gtk my Pamac GUI is now working again as defined. 
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