Do the combos break with a certain layout, or when the option (both Alts change layout) is enabled?
Have you tried other options to change the layout, ie different keys?
Please provide the output of this command.
setxkbmap -print -verbose 10
Could you install evtest and run it please (you may need to run it with sudo).
Select your keyboard from the list and test some of the affected combos, both when they’re working and not working. CTRL + C or CTRL + ALT + C to exit.