This is not only Calibre, also with Transmission. (Replies in the nature of “I don’t have problems with this” do not help).
I remember from some other issues that only a few people recognized, the solution was to delete some configuration files. Thereby forcing the system to re-create that configuration.
My question is: which files probably somewhere in the Home directory would be candidate for this?
Thanks for the link to the arch wiki. maybe HiDPI - ArchWiki.
Added these variables to the environment:
$ export QT_AUTO_SCREEN_SCALE_FACTOR=1
$ export QT_ENABLE_HIGHDPI_SCALING=1