Continuing the discussion from Audio Interface appears to be connected, doesn't play sound. (MSI, Focusrite):
from ALSA data
ALSA controls for Headphone and Rear audio Jack (Front channel Speakers) are both unmuted and set to 100%
but one of the outputs is likely to be muted when system is booted by this control:
Simple mixer control 'Auto-Mute Mode',0
Capabilities: enum
Items: 'Disabled' 'Enabled'
Item0: 'Enabled'
suggest change that setting to Disabled
amixer -c0 sset 'Auto-Mute Mode' Disabled
and save ALSA settings so this control remains disabled when system is booted
sudo alsactl store
when auto-mute is disabled in ALSA, Pulseaudio controls should no longer show audio connections are ‘plugged-in’ or ‘unplugged’ and checking playback sinks in terminal will probably show connections are ‘unknown’
Pulseaudio will not try to avoid using an ‘unknown’ sink like one detected as ‘available:no’
there may also be a potential issue with audio capture from front panel jack
ALSA default control settings show the front microphone connected to both input sources
'Input Source',0 and 'Input Source',1
a microphone connected to front panel jack may not sound so good connected to both ALSA subdevice channels,
changing 'Input Source',1 to Rear Mic or Line In would avoid any problem