I had a program installed directly with wine that worked well. In order to install a game, with POL or Lutris, I followed the tips and installed Winetricks and if I remember Wine-staging instead of Wine.
My 1st program could not be opened anymore. Even after uninstalling all Wine related stuff and reinstalling normal Wine.
I have now specific programs installed with Wine, POL or Lutris, so that I don’t break the configuration.
Maybe an update of your Wine related applications did that.