When your home is on another disk I’d go for a complete reinstall - the settings and configurations are the most tedios to reconstruct. I have recently created a script - fairly customizable - to do the heavy lifting.
I remember another user having done something similar but I couldn’t remember who, where - even keywords - the only thing I remember is that it was targeting KDE - and that is too little to search for - and it is most likely in the archived forum as well.
You could try with Disk2vhd (Disk2vhd - Windows Sysinternals | Microsoft Docs) then convert the result to vbox vm.