I noticed that some game e.g. Dota 2 is completely frozen when playing this game but there is no error message.
I checked Vulkan, OpenGL, different Kernel and mesa, but they don’t help.
I restored a previous Btrfs snapshot, then the issue is gone. I checked every dependency update which caused the issue.
In the end I found the
libx11 18.3-4 is buggy!
libx11 18.3-3 has no issue.
It looks similar to the issue report.