Yes, that is possible. I use ZFS on my dual external drives via SATA connection (not USB connection) for NAS and my second weekly backup.
The solution:
Idea: You can use two separate Kernels running in parallel on the same computer. How?
You need to setup a new KVM/QEMU to connect to ZFS on any drive on the same computer.
I would suggest, try to install TrueNAS SCALE on QEMU/KVM. TrueNAS SCALE OS with Web GUI might be good for ZFS beginners. But I use Arch ZFS LTS that is not easy for beginner.