Audio sporadically cutting out after switching from PulseAudio to PipeWire

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[HowTo] Troubleshoot crackling in PipeWire

Difficulty: ★★☆☆☆ This tutorial will help you get rid of crackling/popping issues in PipeWire and PipeWire-Pulse. Edit: The guide now assumes that you are using wireplumber, pipewire-media-session instructions removed. Tips: Click to expand Short Guide: A much less detailed version of this guide meant for people who more or less know what they’re doing, but are feeling too lazy to be thorough about troubleshooting the issue. The full guide has better potential solutions, but this is the best…

Just go through that and change some of the default settings.