Just draft/pure thoughts
Is it mouse pointer freezing issue like mouse movement sensor stop to respond completely and pointer stucks in some position on display?
Does mouse pointer is visible or it is invisible/absent on the screen?
Check Manjaro power/suspend policies for devices and USB ports (that user found some USB suspend settings (for his case): Troubleshooting USB 3.0 Ethernet adapter).
Check your BIOS/UEFI settings for suspend/resume USB port. Try modes to suspend all, to never suspend. to turn on/off USB 2.0 mode (probably compatibility/legacy mode).
Does that device(s) has updatable firmware? Have lastest version already? May be to try downgrade it to -1, -2 version back and to check?
Does that effect present with every kernel version? May be to try at least couple of LTS (and may be now fixed) and 5.13, 5.14 versions?
How are you bring mouse pointer to live? By re-plug it? By turning wireless mouse off and on by switch on it?
If to re-plug that USB mouse (ot it’s wireless USB receiver), than mouse pointer become movable on screen again?
What manufacturer thinks? Did you open a tech. support ticket at least with the reason of what to try check?
Do you have other hardware?
Does other mouse HW behaves the same way on the PC?
Does other PC HW with the trouble mouse HW behaves the same way?
If the mouse is wireless, do you have re-chargeable battery? If to switch to new non-chargeable energy item, than does this happen again? (may be it need high current on start stage (for example like HDDs need to spin up their disks) and old re-chargeable battery can’t meet that requirements)
It is gaming mouse? Probably you have a HW key on the mouse to switch it’s sensitivity (or key combination - check user manual). May be switching the sensitivity mode (dpi/ppi) will trigger sensor mode and leads to wake it up or just some modes are fails to resume and other works fine.
re-read user manual fully, may be you will get another idea to try. Also read updatable trouble shooting and FAQ sections on it’s website.
if it is wireless mouse, it is possible to change USB receiver to other sample of the same model or other model (and to re-pair receiver w/ mouse)?
try another USB port (2.0/3.0) other side, back side.
visit service center of mouses/keyboards repair(fix): what are their advises?
if wireless did you tried to pair usb receiver and mouse again?
remove any additional adapters between mouse USB receiver (or mouse USB plug) and USB port of PC, so plugin the mouse directly into USB port of PC.
Is it possible to pass additional parameters into suspending mode to make PC to do not suspend USB ports or to suspend, turn off them fully (not some partial mode e.g. half-suspend)?