System Wide Stuttering caused by Opening Programs, Taking Screenshots, etc

There is no need to listen ACPI events on a Desktop PC
https://wiki.archlinux.org/title/NVIDIA/Tips_and_tricks#Listening_to_ACPI_events

Avoids screen tearing
https://wiki.archlinux.org/title/NVIDIA/Troubleshooting#Avoid_screen_tearing

Sometimes is required for KDE plasma to use also

Option         "TripleBuffer"  "On"

Right above the Option "ConnectToAcpid" "Off" - and also creating the kwin.sh as described here

Maybe you also need to enable early KMS