If the speakers were making a ‘POOP’ noise before you replaced PulseAudio with PipeWire, I suggest you disable power-saving in ALSA first
sudo tee /etc/modprobe.d/hda-no-suspend.conf <<< 'options snd_hda_intel power_save=0 power_save_controller=N'
Pops when starting and stopping playback - Advanced Linux Sound Architecture - ArchWiki
If the noise started only after installing PipeWire, there is more than one way to disable suspend-timeout function, depending on which session-manager PipeWire is using - pipewire-media-session or wireplumber
Noticeable audio delay or audible pop/crack when starting playback - PipeWire - ArchWiki
@varikonniemi
Simpler method to disable power saving in Pulseaudio: