error: could not open file /var/lib/pacman/local/python-3.10.6-1/desc: no such file or directory
looking for conflicting packages...
warning: could not fully load metadata for package python-3.10.6-1
error: failed to prepare transaction (invalid or corrupted package)
lets hope this is the only issue you have: sudo touch /var/lib/pacman/local/python-3.10.6-1/desc
reinstall it: sudo pacman -S python --overwrite '*'
we use the overwrite just in case
it will probably give you the same issue again, but this time with files instead of desc, so do the same sudo touch with files and then reinstall again python