I wish someone could have told me earlier…
It’s been a few days now and the game worked quite consistently, crashing about once an hour (I played with a chronometer on so I could be sure how long it was between the crashes). I can play with maximum graphics. It’s amazing, thank you so much @MrLavender and @weingeist for your help!
I’ll mark this thread as solved, as I think crashing once an hour is a pretty big improvement already, and the remaining crashes might be related to something else. Below the launch options that I use now:
DXVK_HUD=full DXVK_FRAME_RATE=60 prime-run %command%
Cheers!