There has only been one discussion here about ALC4080 this year
No sound from optical port (S/PDIF out - Realtek ALC 4080) with MSI MAG X570S Edge Max Wifi Mother Board
This article has good comparison between ALC1220 and ALC4080 codecs
The Realtek ALC4080 on the new Intel boards demystified and the differences to the ALC1220 | Insider | igor’sLAB
The audio specfications are no different, but ALC4080 has additional amplifiers for audio outputs
and might have better audio quality
Audio controls in alsamixer are very similar to ALC1200 codecs, but ALC4080 has an internal USB bus to connect to the additional amplifiers and pre-amplifiers, so ALSA playback and capture devices in aplay -l and arecord -l are shown as USB devices
ALC4080 requires a Use Case Manager configuration to get the USB audio channels lined up correctly
The online source code for package alsa-ucm-conf has a list of motherboards that should work without issues on latest kernels.
One difference that will not matter for most users is the tools like hdajackretask for snd_hda_intel driver do not work for snd_usb_audio driver, but not many users want/need tools to hack internal codec configuration