If you are sure for using full EXT4, you should test your hardware before: CPU cache, wrong binary calculation in CPU, RAM and Disks with different test tools for example: Memtest86+, mprime and linpack etc…
If you feel sure that hardwares are all ok, then you can use EXT4 completely.
Some people have problem that they got a lot of corrupt data without checksum ability when hardware have some issue without easily noticing
For example:
The test tool Memtest86+ can not detect the error of RAM, but BTRFS did.